A cytosine deaminase for programmable single-base RNA editing

Programmable RNA editing enables reversible recoding of RNA information for research and disease treatment. Previously, we developed a programmable A to I RNA editing approach by fusing catalytically inactivated RNA-targeting CRISPR-Cas13 (dCas13) with the adenine deaminase domain of ADAR2. Here, we...

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Pubblicato in:Science
Autori principali: Abudayyeh, Omar O., Gootenberg, Jonathan S., Franklin, Brian, Koob, Jeremy, Kellner, Max J., Ladha, Alim, Joung, Julia, Kirchgatterer, Paul, Cox, David B.T., Zhang, Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956565/
https://ncbi.nlm.nih.gov/pubmed/31296651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax7063
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