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A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
Existing adenine and cytosine base editors induce only a single type of modification, limiting the range of DNA alterations that can be created. Here we describe a CRISPR-Cas9-based synchronous programmable adenine and cytosine editor (SPACE) that can concurrently introduce A-to-G and C-to-T substit...
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| Publicado no: | Nat Biotechnol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7723518/ https://ncbi.nlm.nih.gov/pubmed/32483364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0535-y |
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