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CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
CRISPR-guided DNA cytosine and adenine base editors (CBEs and ABEs) are widely used for many applications(1–4) but primarily create DNA base transitions (i.e., pyrimidine-to-pyrimidine, or purine-to-purine). Here we describe the engineering of two base editor architectures that can efficiently induc...
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| Publicado no: | Nat Biotechnol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7854778/ https://ncbi.nlm.nih.gov/pubmed/32690971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0609-x |
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