Common activation mechanism of class A GPCRs

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for discovering novel therapeutics since about one-third of all marketed drugs target members of this family. GPCR activation is an allosteric pro...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhou, Qingtong, Yang, Dehua, Wu, Meng, Guo, Yu, Guo, Wanjing, Zhong, Li, Cai, Xiaoqing, Dai, Antao, Jang, Wonjo, Shakhnovich, Eugene I, Liu, Zhi-Jie, Stevens, Raymond C, Lambert, Nevin A, Babu, M Madan, Wang, Ming-Wei, Zhao, Suwen
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954041/
https://ncbi.nlm.nih.gov/pubmed/31855179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50279
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