Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening

Allosteric modulators have emerged with many potential pharmacological advantages as they do not compete the binding of agonist or antagonist to the orthosteric sites but ultimately affect downstream signaling. To identify allosteric modulators targeting an extra-helical binding site of the glucagon...

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Udgivet i:Biomolecules
Main Authors: Zhou, Qingtong, Guo, Wanjing, Dai, Antao, Cai, Xiaoqing, Vass, Márton, de Graaf, Chris, Shui, Wenqing, Zhao, Suwen, Yang, Dehua, Wang, Ming-Wei
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301998/
https://ncbi.nlm.nih.gov/pubmed/34201418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11070929
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