The metabolic regulator mTORC1 controls terminal myeloid differentiation

Monocytes are derived from hematopoietic stem cells through a series of intermediate progenitor stages, but the factors that regulate this process are incompletely defined. Using a Ccr2/Cx(3)cr1 dual-reporter system to model murine monocyte ontogeny, we conducted a small molecule screen that identif...

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Publicat a:Sci Immunol
Autors principals: Lee, Pui Y., Sykes, David B., Ameri, Sarah, Kalaitzidis, Demetrios, Charles, Julia F., Nelson-Maney, Nathan, Wei, Kevin, Cunin, Pierre, Morris, Allyn, Cardona, Astrid E., Root, David E., Scadden, David T., Nigrovic, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953719/
https://ncbi.nlm.nih.gov/pubmed/28763796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aam6641
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