Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation

Glutamate dysregulation occurs in multiple sclerosis (MS), but whether excitotoxic mechanisms in mature oligodendrocytes contribute to demyelination and axonal injury is unexplored. Although current treatments modulate the immune system, long-term disability ensues, highlighting the need for neuropr...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Evonuk, Kirsten S., Doyle, Ryan E., Moseley, Carson E., Thornell, Ian M., Adler, Keith, Bingaman, Amanda M., Bevensee, Mark O., Weaver, Casey T., Min, Booki, DeSilva, Tara M.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949032/
https://ncbi.nlm.nih.gov/pubmed/31934627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5936
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