Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation

Glutamate dysregulation occurs in multiple sclerosis (MS), but whether excitotoxic mechanisms in mature oligodendrocytes contribute to demyelination and axonal injury is unexplored. Although current treatments modulate the immune system, long-term disability ensues, highlighting the need for neuropr...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Evonuk, Kirsten S., Doyle, Ryan E., Moseley, Carson E., Thornell, Ian M., Adler, Keith, Bingaman, Amanda M., Bevensee, Mark O., Weaver, Casey T., Min, Booki, DeSilva, Tara M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949032/
https://ncbi.nlm.nih.gov/pubmed/31934627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5936
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