Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation

Glutamate dysregulation occurs in multiple sclerosis (MS), but whether excitotoxic mechanisms in mature oligodendrocytes contribute to demyelination and axonal injury is unexplored. Although current treatments modulate the immune system, long-term disability ensues, highlighting the need for neuropr...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Evonuk, Kirsten S., Doyle, Ryan E., Moseley, Carson E., Thornell, Ian M., Adler, Keith, Bingaman, Amanda M., Bevensee, Mark O., Weaver, Casey T., Min, Booki, DeSilva, Tara M.
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949032/
https://ncbi.nlm.nih.gov/pubmed/31934627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5936
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