ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres

Break-induced replication is a specific type of DNA repair that has a co-opted role in telomere extension by telomerase-negative cancer cells. This Alternative Lengthening of Telomeres (or ‘ALT’) is required for viability in approximately 10% of all carcinomas, but up to 50% of the soft-tissue deriv...

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Bibliografiske detaljer
Udgivet i:Nucleus
Main Authors: O’Rourke, Julienne J, Bythell-Douglas, Rohan, Dunn, Elyse A, Deans, Andrew J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
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Commentary
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949022/
https://ncbi.nlm.nih.gov/pubmed/31663812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2019.1685246
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