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Alternative lengthening of telomeres (ALT) in cancer stem cells in vivo

Chromosome ends are protected by telomeres which prevent DNA damage response and degradation. Telomerase expression extends telomeres and inhibits DNA damage response. Telomeres are also maintained by the recombination based alternative lengthening pathway. Telomerase is believed to be the sole mech...

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Detalhes bibliográficos
Main Authors: Bojovic, Bojana, Booth, Ryan E., Jin, Yi, Zhou, Xiaofeng, Crowe, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135038/
https://ncbi.nlm.nih.gov/pubmed/24531712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.603
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