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Alternative lengthening of telomeres (ALT) in cancer stem cells in vivo
Chromosome ends are protected by telomeres which prevent DNA damage response and degradation. Telomerase expression extends telomeres and inhibits DNA damage response. Telomeres are also maintained by the recombination based alternative lengthening pathway. Telomerase is believed to be the sole mech...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4135038/ https://ncbi.nlm.nih.gov/pubmed/24531712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.603 |
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