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Alternative Lengthening of Telomeres (ALT) in Tumors and Pluripotent Stem Cells
A telomere consists of repeated DNA sequences (TTAGGG)n as part of a nucleoprotein structure at the end of the linear chromosome, and their progressive shortening induces DNA damage response (DDR) that triggers cellular senescence. The telomere can be maintained by telomerase activity (TA) in the ma...
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| Publicado no: | Genes (Basel) |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6947546/ https://ncbi.nlm.nih.gov/pubmed/31835618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10121030 |
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