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The Impact of Minor-Groove N(2)‑Alkyl-2′-deoxyguanosine Lesions on DNA Replication in Human Cells

Endogenous metabolites and exogenous chemicals can induce covalent modifications on DNA, producing DNA lesions. The N(2) of guanine was shown to be a common alkylation site in DNA; however, not much is known about the influence of the size of the alkyl group in N(2)-alkyldG lesions on cellular DNA r...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Wu, Jun, Du, Hua, Li, Lin, Price, Nathan E., Liu, Xiaochuan, Wang, Yinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948715/
https://ncbi.nlm.nih.gov/pubmed/31347832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00129
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