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The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2′-deoxyguanosine lesions in human cells

Exogenous and endogenous chemicals can react with DNA to produce DNA lesions that may block DNA replication. Not much is known about the roles of polymerase (Pol) ν and Pol θ in translesion synthesis (TLS) in cells. Here we examined the functions of these two polymerases in bypassing major-groove O(...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Du, Hua, Wang, Pengcheng, Wu, Jun, He, Xiaomei, Wang, Yinsheng
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135994/
https://ncbi.nlm.nih.gov/pubmed/32098870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012830
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