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The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2′-deoxyguanosine lesions in human cells

Exogenous and endogenous chemicals can react with DNA to produce DNA lesions that may block DNA replication. Not much is known about the roles of polymerase (Pol) ν and Pol θ in translesion synthesis (TLS) in cells. Here we examined the functions of these two polymerases in bypassing major-groove O(...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Du, Hua, Wang, Pengcheng, Wu, Jun, He, Xiaomei, Wang, Yinsheng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135994/
https://ncbi.nlm.nih.gov/pubmed/32098870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012830
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