DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Oncogenic RAS mutations drive cancers at many sites. Recent reports suggest that RAS dimerization, multimerization, and clustering correlate strongly with activation of RAS signaling. We have found that re-expression of DIRAS3, a RAS-related small GTPase tumor suppressor that is downregulated in mul...

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Pubblicato in:Cell Rep
Autori principali: Sutton, Margie N., Lu, Zhen, Li, Yao-Cheng, Zhou, Yong, Huang, Tao, Reger, Albert S., Hurwitz, Amy M., Palzkill, Timothy, Logsdon, Craig, Liang, Xiaowen, Gray, Joe W., Nan, Xiaolin, Hancock, John, Wahl, Geoffrey M., Bast, Robert C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948147/
https://ncbi.nlm.nih.gov/pubmed/31825828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.045
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