ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7

The process of autophagy has been described in detail at the molecular level in normal cells, but less is known of its regulation in cancer cells. Aplasia Ras homolog member I (ARHI; DIRAS3) is an imprinted tumor suppressor gene that is downregulated in multiple malignancies including ovarian cancer...

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Detalhes bibliográficos
Main Authors: Lu, Z, Yang, H, Sutton, M N, Yang, M, Clarke, C H, Liao, W S-L, Bast, R C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085535/
https://ncbi.nlm.nih.gov/pubmed/24769729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.48
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