Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models

BACKGROUND: Autophagy is a bulk catabolic process that modulates tumorigenesis, therapeutic resistance, and dormancy. The tumor suppressor ARHI (DIRAS3) is a potent inducer of autophagy and its expression results in necroptotic cell death in vitro and tumor dormancy in vivo. ARHI is down-regulated o...

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Dettagli Bibliografici
Pubblicato in:BMC Cancer
Autori principali: Ornelas, Argentina, McCullough, Christopher R., Lu, Zhen, Zacharias, Niki M., Kelderhouse, Lindsay E., Gray, Joshua, Yang, Hailing, Engel, Brian J., Wang, Yan, Mao, Weiqun, Sutton, Margie N., Bhattacharya, Pratip K., Bast, Robert C., Millward, Steven W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080741/
https://ncbi.nlm.nih.gov/pubmed/27784287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2850-8
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