Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models

BACKGROUND: Autophagy is a bulk catabolic process that modulates tumorigenesis, therapeutic resistance, and dormancy. The tumor suppressor ARHI (DIRAS3) is a potent inducer of autophagy and its expression results in necroptotic cell death in vitro and tumor dormancy in vivo. ARHI is down-regulated o...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Ornelas, Argentina, McCullough, Christopher R., Lu, Zhen, Zacharias, Niki M., Kelderhouse, Lindsay E., Gray, Joshua, Yang, Hailing, Engel, Brian J., Wang, Yan, Mao, Weiqun, Sutton, Margie N., Bhattacharya, Pratip K., Bast, Robert C., Millward, Steven W.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080741/
https://ncbi.nlm.nih.gov/pubmed/27784287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2850-8
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