RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells

Among the 3 GTPases in the DIRAS family, DIRAS3/ARHI is the best characterized. DIRAS3 is an imprinted tumor suppressor gene that encodes a 26-kDa GTPase that shares 60% homology to RAS and RAP. DIRAS3 is downregulated in many tumor types, including ovarian cancer, where re-expression inhibits cance...

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Udgivet i:Autophagy
Main Authors: Sutton, Margie N., Yang, Hailing, Huang, Gilbert Y., Fu, Caroline, Pontikos, Michael, Wang, Yan, Mao, Weiqun, Pang, Lan, Yang, Maojie, Liu, Jinsong, Parker-Thornburg, Jan, Lu, Zhen, Bast, Robert C.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Papers - Basic Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959337/
https://ncbi.nlm.nih.gov/pubmed/29368982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1427022
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