Blockade of glutathione metabolism in IDH1-mutated glioma

Mutations in genes encoding isocitrate dehydrogenases (IDHs) 1 and 2 are common cancer-related genetic abnormalities. Malignancies with mutated IDHs exhibit similar pathogenesis, metabolic pattern, and resistance signature. However, an effective therapy against IDH1-mutated solid tumor remains unava...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Tang, Xiaoying, Fu, Xiao, Liu, Yang, Yu, Di, Cai, Sabrina J., Yang, Chunzhang
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946871/
https://ncbi.nlm.nih.gov/pubmed/31548295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0103
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