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Progress Toward Eukaryotic Semi-Synthetic Organisms: Translation of Unnatural Codons

We have created a bacterial semi-synthetic organism (SSO) that retains an unnatural base pair (UBP) in its DNA, transcribes it into mRNA and tRNA with cognate unnatural codons and anticodons, and after the tRNA is charged with a non-canonical amino acid, synthesizes proteins containing the non-canon...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Zhou, Anne Xiao-Zhou, Sheng, Kai, Feldman, Aaron W., Romesberg, Floyd E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946121/
https://ncbi.nlm.nih.gov/pubmed/31841336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b09080
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