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Prediction of Conformation Specific Thermostabilizing Mutations for Class A GPCRs
G protein-coupled receptors (GPCRs) are highly flexible and prone to denaturation during protein extraction in detergents, and purification. This poses a huge challenge to purify conformationally homogenous solution of GPCRs. Thermostabilizing mutations have been used widely to purify and obtain cry...
Enregistré dans:
| Publié dans: | J Chem Inf Model |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6944194/ https://ncbi.nlm.nih.gov/pubmed/31408606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.9b00175 |
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