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Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype

In this issue, the Gabrielli laboratory and collaborators address the bulky CPD lesions created in DNA when UV joins two adjacent pyrimidines (thymine or cytosine), leading to skin cancers such as melanoma (Pavey S et al. (2019) Mol Oncol). Our understanding of postreplication repair mechanisms for...

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Publicat a:Mol Oncol
Autors principals: Brash, Douglas E., Seidman, Michael M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944110/
https://ncbi.nlm.nih.gov/pubmed/31821728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12612
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