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Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype

In this issue, the Gabrielli laboratory and collaborators address the bulky CPD lesions created in DNA when UV joins two adjacent pyrimidines (thymine or cytosine), leading to skin cancers such as melanoma (Pavey S et al. (2019) Mol Oncol). Our understanding of postreplication repair mechanisms for...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Brash, Douglas E., Seidman, Michael M.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944110/
https://ncbi.nlm.nih.gov/pubmed/31821728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12612
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