MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma

The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrichment analysis and proteomic screening, and identif...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cancer Res
Autores principales: Zhang, Yiru, Nguyen, Trang T. T., Shang, Enyuan, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Zhao, Junfei, Shu, Chang, Torrini, Consuelo, Sanchez-Quintero, Maria J., Kleiner, Giulio, Bianchetti, Elena, Westhoff, Mike-Andrew, Quinzii, Catarina M., Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942623/
https://ncbi.nlm.nih.gov/pubmed/31694905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1389
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares