MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma

The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrichment analysis and proteomic screening, and identif...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Zhang, Yiru, Nguyen, Trang T. T., Shang, Enyuan, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Zhao, Junfei, Shu, Chang, Torrini, Consuelo, Sanchez-Quintero, Maria J., Kleiner, Giulio, Bianchetti, Elena, Westhoff, Mike-Andrew, Quinzii, Catarina M., Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942623/
https://ncbi.nlm.nih.gov/pubmed/31694905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1389
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