MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma

The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrichment analysis and proteomic screening, and identif...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Zhang, Yiru, Nguyen, Trang T. T., Shang, Enyuan, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Zhao, Junfei, Shu, Chang, Torrini, Consuelo, Sanchez-Quintero, Maria J., Kleiner, Giulio, Bianchetti, Elena, Westhoff, Mike-Andrew, Quinzii, Catarina M., Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942623/
https://ncbi.nlm.nih.gov/pubmed/31694905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1389
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