MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma

The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrichment analysis and proteomic screening, and identif...

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Библиографические подробности
Опубликовано в: :Cancer Res
Главные авторы: Zhang, Yiru, Nguyen, Trang T. T., Shang, Enyuan, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Zhao, Junfei, Shu, Chang, Torrini, Consuelo, Sanchez-Quintero, Maria J., Kleiner, Giulio, Bianchetti, Elena, Westhoff, Mike-Andrew, Quinzii, Catarina M., Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942623/
https://ncbi.nlm.nih.gov/pubmed/31694905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1389
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