HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models

The Warburg effect is a tumor-related phenomenon that could potentially be targeted therapeutically. Here, we showed that glioblastoma (GBM) cultures and patients’ tumors harbored super-enhancers in several genes related to the Warburg effect. By conducting a transcriptome analysis followed by ChIP-...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Nguyen, Trang Thi Thu, Zhang, Yiru, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhao, Junfei, Bianchetti, Elena, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Harmanci, Arif O., Lei, Zhengdeng, Maienschein-Cline, Mark, Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324177/
https://ncbi.nlm.nih.gov/pubmed/32315286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129049
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