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Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues
Dysregulation of the hedgehog (Hh) signaling pathway is associated with cancer occurrence and development in various malignancies. Previous structure-activity relationships (SAR) studies have provided potent Itraconazole (ITZ) analogues as Hh pathway antagonists. To further expand on our SAR for the...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6942223/ https://ncbi.nlm.nih.gov/pubmed/31761657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126794 |
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