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Development of Posaconazole-based Analogues as Hedgehog Signaling Pathway Inhibitors
Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful triazole anti-fungals that are being repurposed as anti-cancer...
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| Udgivet i: | Eur J Med Chem |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6358021/ https://ncbi.nlm.nih.gov/pubmed/30529635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.11.056 |
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