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Development of Posaconazole-based Analogues as Hedgehog Signaling Pathway Inhibitors

Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful triazole anti-fungals that are being repurposed as anti-cancer...

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Detalles Bibliográficos
Publicado en:Eur J Med Chem
Main Authors: Teske, Kelly A., Dash, Radha Charan, Morel, Shana R., Chou, Lianne Q., Wechsler-Reya, Robert J., Hadden, M. Kyle
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358021/
https://ncbi.nlm.nih.gov/pubmed/30529635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.11.056
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