Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor

The glioma-associated family of transcription factors (GLI) have emerged as a promising therapeutic target for a variety of human cancers. In particular, GLI1 plays a central role as a transcriptional regulator for multiple oncogenic signaling pathways, including the hedgehog (Hh) signaling pathway....

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Dash, Radha Charan, Wen, Jiachen, Zaino, Angela M., Morel, Shana R., Chau, Lianne Q., Wechsler-Reya, Robert J., Hadden, M. Kyle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873571/
https://ncbi.nlm.nih.gov/pubmed/33614910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2021.01.004
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