Characterizing and Minimizing Aggregation and Particle Formation of Three Recombinant Fusion-Protein Bulk Antigens for Use in a Candidate Trivalent Rotavirus Vaccine

In a companion paper, the structural integrity, conformational stability, and degradation mechanisms of 3 recombinant fusion-protein antigens comprising a non-replicating rotavirus (NRRV) vaccine candidate (currently being evaluated in early-stage clinical trials) are described. In this work, we foc...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Agarwal, Sanjeev, Sahni, Neha, Hickey, John M., Robertson, George A., Sitrin, Robert, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2020
Assuntos:
Pharmaceutical Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941221/
https://ncbi.nlm.nih.gov/pubmed/31400346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.08.001
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