Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens

A nonreplicating rotavirus vaccine (NRRV) containing 3 recombinant fusion proteins adsorbed to aluminum adjuvant (Alhydrogel [AH]) is currently in clinical trials. The compatibility and stability of monovalent NRRV antigen with key components of a multidose vaccine formulation were examined using ph...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Agarwal, Sanjeev, Hickey, John M., McAdams, David, White, Jessica A., Sitrin, Robert, Khandke, Lakshmi, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941222/
https://ncbi.nlm.nih.gov/pubmed/31589875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.10.004
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