Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

BACKGROUND: Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the inherent biophysical traits presented by an individual antigen of interest. N...

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發表在:Microb Cell Fact
Main Authors: Dalvie, Neil C., Brady, Joseph R., Crowell, Laura E., Tracey, Mary Kate, Biedermann, Andrew M., Kaur, Kawaljit, Hickey, John M., Kristensen, D. Lee, Bonnyman, Alexandra D., Rodriguez-Aponte, Sergio A., Whittaker, Charles A., Bok, Marina, Vega, Celina, Mukhopadhyay, Tarit K., Joshi, Sangeeta B., Volkin, David B., Parreño, Viviana, Love, Kerry R., Love, J. Christopher
格式: Artigo
語言:Inglês
出版: BioMed Central 2021
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088319/
https://ncbi.nlm.nih.gov/pubmed/33933073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01583-6
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