Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

A two-step developability assessment workflow is described to screen variants of recombinant protein antigens under various formulation conditions to rapidly identify stable, aluminum-adjuvanted, multi-dose vaccine candidates. For proof-of-concept, a series of sequence variants of the recombinant no...

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發表在:J Pharm Sci
Main Authors: Sawant, Nishant, Kaur, Kawaljit, Holland, David A., Hickey, John M., Agarwal, Sanjeev, Brady, Joseph R., Dalvie, Neil C., Tracey, Mary Kate, Velez-Suberbie, M. Lourdes, Morris, Stephen A., Jacob, Shaleem I., Bracewell, Daniel G., Mukhopadhyay, Tarit K., Love, Kerry R., Love, J. Christopher, Joshi, Sangeeta B., Volkin, David B.
格式: Artigo
語言:Inglês
出版: Elsevier 2021
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884052/
https://ncbi.nlm.nih.gov/pubmed/33285182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2020.11.039
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