Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine

In a companion paper, a two-step developability assessment is presented to rapidly evaluate low-cost formulations (multi-dose, aluminum-adjuvanted) for new subunit vaccine candidates. As a case study, a non-replicating rotavirus (NRRV) recombinant protein antigen P[4] was found to be destabilized by...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Kaur, Kawaljit, Xiong, Jian, Sawant, Nishant, Agarwal, Sanjeev, Hickey, John M., Holland, David A., Mukhopadhyay, Tarit K., Brady, Joseph R., Dalvie, Neil C., Tracey, Mary Kate, Love, Kerry R., Love, J. Christopher, Weis, David D., Joshi, Sangeeta B., Volkin, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884053/
https://ncbi.nlm.nih.gov/pubmed/33278412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2020.11.033
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