Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine

In a companion paper, a two-step developability assessment is presented to rapidly evaluate low-cost formulations (multi-dose, aluminum-adjuvanted) for new subunit vaccine candidates. As a case study, a non-replicating rotavirus (NRRV) recombinant protein antigen P[4] was found to be destabilized by...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Pharm Sci
Päätekijät: Kaur, Kawaljit, Xiong, Jian, Sawant, Nishant, Agarwal, Sanjeev, Hickey, John M., Holland, David A., Mukhopadhyay, Tarit K., Brady, Joseph R., Dalvie, Neil C., Tracey, Mary Kate, Love, Kerry R., Love, J. Christopher, Weis, David D., Joshi, Sangeeta B., Volkin, David B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2021
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884053/
https://ncbi.nlm.nih.gov/pubmed/33278412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2020.11.033
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