Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis

MtmOIV and MtmW catalyze the final two reactions in the mithramycin (MTM) biosynthetic pathway, the Baeyer-Villiger opening of the fourth ring of premithramycin B (PMB), creating the C3 pentyl side chain, strictly followed by reduction of the distal keto group on the new side chain. Unexpectedly thi...

Full description

Saved in:
Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Wheeler, Ryan, Yu, Xia, Hou, Caixia, Mitra, Prithiba, Chen, Jhong-Min, Herkules, Frank, Ivanov, Dmitri N., Tsodikov, Oleg V., Rohr, Jürgen
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940538/
https://ncbi.nlm.nih.gov/pubmed/31702856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201910241
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items