Small Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Small molecules that directly target MYC and are also well tolerated in vivo will provide invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a series of small molecule MYC inhibitors that engage MYC inside cells, disrupt MYC/MAX dimers, and impair MYC-driven gene e...

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Publicat a:Cancer Cell
Autors principals: Han, Huiying, Jain, Atul D., Truica, Mihai I., Izquierdo-Ferrer, Javier, Anker, Jonathan F., Lysy, Barbara, Sagar, Vinay, Luan, Yi, Chalmers, Zachary R., Kenji Unno, Mok, Hanlin, Vatapalli, Rajita, Yoo, Young A, Rodriguez, Yara, Kandela, Irawati, Parker, J. Brandon, Chakravarti, Debabrata, Mishra, Rama K., Schiltz, Gary E., Abdulkadir, Sarki A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939458/
https://ncbi.nlm.nih.gov/pubmed/31679823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.10.001
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