Activated ALK Cooperates with N-Myc via Wnt/β-catenin Signaling to Induce Neuroendocrine Prostate Cancer

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer with poor prognosis, and there is a critical need for novel therapeutic approaches. NEPC is associated with molecular perturbation of several pathways including amplification of MYCN. Anaplastic lymphoma kinase (ALK) i...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Unno, Kenji, Chalmers, Zachary R., Pamarthy, Sahithi, Vatapalli, Rajita, Rodriguez, Yara, Lysy, Barbara, Mok, Hanlin, Sagar, Vinay, Han, Huiying, Yoo, Young A, Ku, Sheng-Yu, Beltran, Himisha, Zhao, Yue, Abdulkadir, Sarki A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137566/
https://ncbi.nlm.nih.gov/pubmed/33637566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-3351
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