Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in prostate cancer (PCa) is undefined. Here we show that DOT1L is overexpressed in PCa and is associated with poor outcome. Genetic an...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Vatapalli, R., Sagar, V., Rodriguez, Y., Zhao, J. C., Unno, K., Pamarthy, S., Lysy, B., Anker, J., Han, H., Yoo, Y. A., Truica, M., Chalmers, Z. R., Giles, F., Yu, J., Chakravarti, D., Carneiro, B., Abdulkadir, S. A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438336/
https://ncbi.nlm.nih.gov/pubmed/32814769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18013-7
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन