Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in prostate cancer (PCa) is undefined. Here we show that DOT1L is overexpressed in PCa and is associated with poor outcome. Genetic an...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Vatapalli, R., Sagar, V., Rodriguez, Y., Zhao, J. C., Unno, K., Pamarthy, S., Lysy, B., Anker, J., Han, H., Yoo, Y. A., Truica, M., Chalmers, Z. R., Giles, F., Yu, J., Chakravarti, D., Carneiro, B., Abdulkadir, S. A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438336/
https://ncbi.nlm.nih.gov/pubmed/32814769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18013-7
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