Small Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Small molecules that directly target MYC and are also well tolerated in vivo will provide invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a series of small molecule MYC inhibitors that engage MYC inside cells, disrupt MYC/MAX dimers, and impair MYC-driven gene e...

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Foilsithe in:Cancer Cell
Main Authors: Han, Huiying, Jain, Atul D., Truica, Mihai I., Izquierdo-Ferrer, Javier, Anker, Jonathan F., Lysy, Barbara, Sagar, Vinay, Luan, Yi, Chalmers, Zachary R., Kenji Unno, Mok, Hanlin, Vatapalli, Rajita, Yoo, Young A, Rodriguez, Yara, Kandela, Irawati, Parker, J. Brandon, Chakravarti, Debabrata, Mishra, Rama K., Schiltz, Gary E., Abdulkadir, Sarki A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939458/
https://ncbi.nlm.nih.gov/pubmed/31679823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.10.001
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