Targeting PDZ Binding Kinase Is Anti-tumorigenic in Novel Preclinical Models of ACC

Adrenocortical carcinoma (ACC) is an aggressive orphan malignancy with less than 35% 5-year survival and 75% recurrence. Surgery remains the primary therapy and Mitotane, an adrenolytic, is the only FDA approved drug with wide range toxicities and poor tolerability. There are no targeted agents avai...

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Vydáno v:Endocr Relat Cancer
Hlavní autoři: Kar, Adwitiya, Zhang, Yu, Yacob, Betelehem W., Saeed, Jordan, Tompkins, Kenneth D., Bagby, Stacey M., Pitts, Todd M., Somerset, Hilary, Leong, Stephen, Wierman, Margaret E., Kiseljak-Vassiliades, Katja
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938568/
https://ncbi.nlm.nih.gov/pubmed/31325906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-19-0262
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