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Targeting PDZ Binding Kinase Is Anti-tumorigenic in Novel Preclinical Models of ACC

Adrenocortical carcinoma (ACC) is an aggressive orphan malignancy with less than 35% 5-year survival and 75% recurrence. Surgery remains the primary therapy and Mitotane, an adrenolytic, is the only FDA approved drug with wide range toxicities and poor tolerability. There are no targeted agents avai...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Endocr Relat Cancer
Main Authors: Kar, Adwitiya, Zhang, Yu, Yacob, Betelehem W., Saeed, Jordan, Tompkins, Kenneth D., Bagby, Stacey M., Pitts, Todd M., Somerset, Hilary, Leong, Stephen, Wierman, Margaret E., Kiseljak-Vassiliades, Katja
פורמט: Artigo
שפה:Inglês
יצא לאור: 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938568/
https://ncbi.nlm.nih.gov/pubmed/31325906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-19-0262
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