A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, and serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), ena...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Davidsson, Marcus, Wang, Gang, Aldrin-Kirk, Patrick, Cardoso, Tiago, Nolbrant, Sara, Hartnor, Morgan, Mudannayake, Janitha, Parmar, Malin, Björklund, Tomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936499/
https://ncbi.nlm.nih.gov/pubmed/31818949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910061116
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