A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, and serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), ena...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Davidsson, Marcus, Wang, Gang, Aldrin-Kirk, Patrick, Cardoso, Tiago, Nolbrant, Sara, Hartnor, Morgan, Mudannayake, Janitha, Parmar, Malin, Björklund, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936499/
https://ncbi.nlm.nih.gov/pubmed/31818949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910061116
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