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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the...
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| Опубликовано в: : | J Mol Cell Biol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6934151/ https://ncbi.nlm.nih.gov/pubmed/30860577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz020 |
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