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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the...

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Vydáno v:J Mol Cell Biol
Hlavní autoři: Wang, Yufang, Shi, Peiliang, Chen, Qin, Huang, Zan, Zou, Dayuan, Zhang, Jingzi, Gao, Xiang, Lin, Zhaoyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934151/
https://ncbi.nlm.nih.gov/pubmed/30860577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz020
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