GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leu...

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Bibliografiske detaljer
Udgivet i:J Mol Cell Biol
Main Authors: Chen, Qin, Shi, Peiliang, Wang, Yufang, Zou, Dayuan, Wu, Xiuwen, Wang, Dingyu, Hu, Qiongyuan, Zou, Yujie, Huang, Zan, Ren, Jianan, Lin, Zhaoyu, Gao, Xiang
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734491/
https://ncbi.nlm.nih.gov/pubmed/30321352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjy056
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