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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the...
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| Publicado no: | J Mol Cell Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6934151/ https://ncbi.nlm.nih.gov/pubmed/30860577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz020 |
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