Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma

Metformin, an ancient drug commonly used for treating type II diabetes, has been associated to anti-cancer capacity in a variety of developing cancers, though the mechanism remains elusive. Here, we aimed to examine the inhibitory effect of metformin in osteosarcoma. Herein, we demonstrated that met...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Int J Biol Sci
Main Authors: Li, Bo, Zhou, Pingting, Xu, Kehan, Chen, Tianrui, Jiao, Jian, Wei, Haifeng, Yang, Xinghai, Xu, Wei, Wan, Wei, Xiao, Jianru
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2020
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930379/
https://ncbi.nlm.nih.gov/pubmed/31892847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.33787
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