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Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study

Osteosarcoma is the most common primary malignant tumor of bone, the long-term survival of which has stagnated in the past several decades. Celastrol, a triterpene from traditional Chinese medicine, has been proved to possess potent anti-tumor effect on various cancers. However, the effect of celast...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, H-Y, Zhang, J, Sun, L-L, Li, B-H, Gao, H-L, Xie, T, Zhang, N, Ye, Z-M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669742/
https://ncbi.nlm.nih.gov/pubmed/25611379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.543
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